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KMID : 0370219980420010108
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Yakhak Hoeji
1998 Volume.42 No. 1 p.108 ~ p.113
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Hepatoprotective Effect of G009 on CCl4-induced Hepatotoxicity in Primary Cultured Rat Hepatocytes
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이미경/Lee MK
김홍표/이준우/정훈/이승룡/김영중/Kim HP/Lee JW/Jung H/Lee SY/Kim YC
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Abstract
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G009, a polysaccharide isolated from the mycelia of Ganoderma lucidum IYO09, showed a hepatoprotective activity against CCl4 induced cytotoxicity in primary cu ltured rat hepatocytes. Incubation of CCl4-intoxicated hepatocytes with G009 significantly reduced the levels of glutamic pyruvic transaminase and sorbitol dehydrogenase released from hepatocytes in the medium. G009 showed antioxidative effect by elevating the activities of glutathione reductase and superoxide dismutase, and the content of glutathione in CCl4-intoxidcated primary cultured rat hepatocytes. Furthermore, G009 significantly elevated glutathione-S-transferase activity in CCl4-intoxicated primary cultured rat hepatocytes. G009 also reduced the production of malondialdehyde, a byproduct of lipid peroxidation. From these results, it could be concluded that G009 exerted hepatoprotective activity against CCl4-induced cytotoxicity through antioxidation.
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